Bibliography Record
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Zahin, Maryam; Ghim, Shin-je; Khanal, Sujita; Bossart, Gregory D.; Jenson, Alfred B.; Joh, Joongho
(detail)
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2015 |
Molecular characterization of novel mucosotropic papillomaviruses from a Florida manatee (Trichechus manatus latirostris).
The Journal of General Virology. DOI: 10.1099/jgv.0.000293. Published online September 21, 2015.
–ABSTRACT: We isolated two new manatee papillomavirus (PV) types, TmPV3 and TmPV4, from a Florida manatee. Two PV types were previously isolated from this species. TmPV1 is widely dispersed among manatees and a close to root PV; not much is known about TmPV2. The genomes of TmPV3 and TmPV4 were 7,622 and 7,771 bp in size, respectively. Both PVs had a genomic organization characteristic to all PVs, with one non-coding region (NCR) and seven open reading frames (ORFs), including the E7 ORF that is absent in other cetacean PVs. Although these PVs were isolated from separate genital lesions of the same manatee, an enlarged E2/E4 ORF was found only in the TmPV4 genome. The full genome and L1 sequence similarities between TmPV3 and TmPV4 were 63.2% and 70.3%, respectively. These genomes shared only 49.1% and 50.2% similarity with TmPV1. The pairwise alignment of L1 nucleotide sequences indicated that the two new PVs nested in a monophyletic group of the Rhopapillomavirus genus, together with the cutaneotropic TmPV1 and TmPV2.
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